Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopesArticle Published on 2022-12-132023-07-10 Journal: Immunity [Category] COVID19(2023년), [키워드] coronavirus COVID-19 Cryo-electron microscopy mosaic nanoparticle Neutralizing antibodies sarbecovirus SARS-CoV-2 Vaccine design. X-ray crystallography [DOI] 10.1016/j.immuni.2022.10.019 PMC 바로가기
Structural heterogeneity and precision of implications drawn from cryo-electron microscopy structures: SARS-CoV-2 spike-protein mutations as a test caseArticle Published on 2022-12-012023-07-10 Journal: European Biophysics Journal [Category] COVID19(2023년), [키워드] Computer models Cryo-electron microscopy mutations Spike protein Structural heterogeneity. [DOI] 10.1007/s00249-022-01619-8 PMC 바로가기
An outlook on potential protein targets of COVID-19 as a druggable siteArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] approved cause claimed clinical trial combating contagious COVID-19 COVID-19 disease Cryo-electron microscopy Delta Efficacy feature genomic help host cell host protein infecting inhibit mechanism of action MERS-CoV Mutation non-structural proteins omicron pandemic Protein Protein target proteolytic cleavage raised Repurposed drug required SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein shown similarity spike Spike protein strain suggested the vaccine therapeutic drugs therapeutic interventions Vaccines. variants of SARS-CoV-2 viral infection virus Wuhan X-ray diffraction [DOI] 10.1007/s11033-022-07724-3 PMC 바로가기
On the Recognition of Natural Substrate CTP and Endogenous Inhibitor ddhCTP of SARS-CoV-2 RNA-Dependent RNA Polymerase: A Molecular Dynamics StudyArticle Published on 2022-10-242022-11-15 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 치료제, [키워드] absence affecting Antiviral computational method COVID-19 outbreak Cryo-electron microscopy cytidine Dynamics endogenous enzyme help implication in silico information inhibitor inhibitory innate immune response investigated MD simulation mechanism molecular molecular mechanism multiple mutation natural novel coronavirus SARS-CoV-2 nucleotide pandemic Protein RdRP RdRp active site Recognition responsible RNA RNA sequence RNA-dependent RNA polymerase SARS-CoV-2 substrate viral replication virus [DOI] 10.1021/acs.jcim.2c01002 PMC 바로가기
Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding AffinityArticle Published on 2022-09-202022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료법, 치료제, [키워드] acute respiratory syndrome adopted affinity analysis anti-SARS-CoV-2 anti-viral activity approved binding affinity binding free energy ChEMBL Chemistry clinical development Compound coronavirus coronavirus disease COVID-19 Cryo-electron microscopy cryo-EM cryo-EM structure database docking drug drug candidates drug library drug repositioning drugs dsRNA fragment molecular orbital calculation Frequency frequency analysis interactions mode molecular Novel coronavirus ONIOM geometry optimization calculation pathogenic PDB performed predicted quantum quantum chemistry calculation RdRP reported reproduction RNA RNA-dependent RNA polymerase SARS-CoV-2 Screening screenings significantly suggested Treatment Virtual screening virtual screening. was performed [DOI] 10.3390/ijms231911009 PMC 바로가기
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSARS-CoV-2 항체의 구조 연구는 스파이크 삼량체를 분해하여 오미크론 변이체를 중화하는 광범위한 항체를 식별합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation antibody caused conservation conserved convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy cryo-EM develop Effectiveness electron microscopy epitope Epitopes function hidden IgG Immune escape investigated monoclonal antibodies monoclonal antibody NAb NAbs neutralize Neutralizing antibodies neutralizing antibody neutralizing antibody. omicron Omicron variant pandemic Protein pseudovirus raised raising RBD reagent Receptor binding Receptor binding domain respiratory S trimer S trimers SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants steric hindrance subset target the SARS-CoV-2 the Spike therapeutic therapy trimer Vaccines variant variants of SARS-CoV-2 virion virus VoC VOCs [DOI] 10.1128/jvi.00480-22 PMC 바로가기 [Article Type] Article
A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination감염 및 백신 접종 후 표적화된 SARS-CoV-2 스파이크의 SD1 도메인에 대한 중화 에피토프Article Published on 2022-08-232022-09-12 Journal: Cell Reports [Category] SARS, 진단, [키워드] acute respiratory syndrome antibody bind canonical coronavirus CP: Immunology CP: Microbiology Cryo-electron microscopy cryo-EM cryogenic electron microscopy domain elicited epitope glycoprotein hydrogen-deuterium exchange identify Immune escape Infection N-terminal domain neutralization Neutralizing Neutralizing antibodies neutralizing antibody neutralizing epitope NTD omicron predominant prefusion RBD Receptor binding domain Region Research SARS-CoV-2 SARS-CoV-2 spike shown spike subdomain 1. target the SARS-CoV-2 vaccination Vaccine development while [DOI] 10.1016/j.celrep.2022.111276 PMC 바로가기 [Article Type] Article
The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2SARS-CoV와 SARS-CoV-2 사이의 다양한 보존된 에피토프를 표적으로 하는 항체의 중화 폭Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] antibody Antibody therapeutics Beta Beta variant breadth broad neutralizing antibody Candidates class complex conserved conversed epitopes COVID-19 cross-neutralizing antibody cryo Cryo-electron microscopy defined Delta effective electron microscopy epitope Epitopes evade exhibited hamsters immunization Infection Microscopy NAb NAbs neutralization Neutralizing Neutralizing antibodies neutralizing antibody offer omicron Omicron variant Omicron variants pseudoviruses Receptor-binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody Spike proteins Structure structure. the receptor-binding domain the spike protein Treatment treatment of COVID-19 Vaccine variant variants variants of concern variants of SARS-CoV-2 Viral [DOI] 10.1073/pnas.2204256119 PMC 바로가기 [Article Type] Article
Structure of SARS-CoV-2 membrane protein essential for virus assembly바이러스 조립에 필수적인 SARS-CoV-2 막 단백질의 구조Article Published on 2022-08-052022-09-11 Journal: Nature Communications [Category] SARS, 변종, 치료법, [키워드] analysis component composed conformational changes conformations conserved coronavirus cryo Cryo-electron microscopy domain domains electron microscopy form hinge region Interaction ion channel M protein mechanism membrane protein morphogenesis nucleocapsid protein oligomers ORF3a Protein recruitment RNA SARS-CoV-2 SARS-CoV-2 ORF3a structural protein Structure the SARS-CoV-2 therapeutic intervention transmembrane virus [DOI] 10.1038/s41467-022-32019-3 PMC 바로가기 [Article Type] Article
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeysArticle Published on 2022-07-252022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] class Combination Complete complex Cryo-electron microscopy Donor epitope Fab Human monoclonal antibody identify in vitro less mAb monoclonal antibody Mutation neutralization neutralize Neutralizing activity omicron other variant Prophylactic reported SARS-CoV-2 SARS-CoV-2 mutant sequence spike epitope tested therapeutic therapy Transmission vaccine-mediated immunity variant [DOI] 10.1038/s41564-022-01198-6 [Article Type] Article